| The impact of gestational diabetes mellitus on pregnancy outcome comparing different cut-off criteria for abnormal glucose tolerance. | |
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MedLine Citation:
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PMID: 21050147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: to examine pregnancy outcomes in relation to different categories of glucose tolerance during pregnancy. DESIGN: prospective observational cohort study. SETTING: patient recruitment and data collection were performed in four delivery departments in southern Sweden. POPULATION: women delivering during 2003-2005; 306 with gestational diabetes mellitus, 744 with gestational impaired glucose tolerance and 329 randomly selected controls. METHODS: all women were offered a 75 g oral glucose tolerance test during pregnancy. On the basis of their capillary 2-hour plasma glucose concentrations, three groups were identified: gestational diabetes mellitus (>10.0 mmol/l), gestational impaired glucose tolerance (8.6-9.9 mmol/l) and controls (<8.6 mmol/l). Data for the groups were compared using a population-based database. MAIN OUTCOME MEASURES: maternal and fetal outcomes. RESULTS: for the gestational diabetes mellitus group, adjusted odds ratios (95% confidence intervals) for hypertensive disorders during pregnancy and induction of labor and emergency cesarean section were 2.7 (1.3-5.8), 3.1 (1.8-5.2) and 2.5 (1.5-4.4), respectively; and for Apgar score <7 at 5 minutes, need for neonatal intensive care >1 day and large-for-gestational age infant were 9.6 (1.2-78.0), 5.2 (2.8-9.6) and 2.5 (1.3-5.1), respectively. The increases in odds ratios for the gestational impaired glucose tolerance group were less pronounced but still significant for hypertension during pregnancy, induction of labor, large-for-gestational age infant and use of neonatal intensive care >1 day, with odds ratios (95% confidence interval) 2.0 (1.0-4.1), 1.8 (1.1-3.0), 2.1 (1.1-3.9) and 2.1 (1.1-3.8), respectively. CONCLUSIONS: these data indicate that even limited degrees of maternal hyperglycemia may affect the outcome of pregnancy. |
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Authors:
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Eva Anderberg; Karin Källén; Kerstin Berntorp |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-05 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 1532-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology in Lund, Skåne University Hospital, Lund University, Sweden. eva.k.anderberg@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Apgar Score Blood Glucose / metabolism* Case-Control Studies Cohort Studies Confidence Intervals Delivery, Obstetric / methods Diabetes, Gestational / blood, diagnosis* Female Follow-Up Studies Gestational Age Glucose Intolerance / diagnosis*, epidemiology Glucose Tolerance Test Humans Infant, Newborn Middle Aged Odds Ratio Pregnancy Pregnancy Outcome* Prospective Studies Reference Values Risk Assessment Severity of Illness Index Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
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