| The impact of genetic and environmental influences on blood pressure variance across age-groups. | |
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MedLine Citation:
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PMID: 11403347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of the present investigation was to examine the age-dependency of blood pressure heritability by use of the twin method in different age groups. DESIGN: In 272 (150 monozygous and 122 dizygous) twin pairs, aged 18 to 76 years, both conventional and ambulatory blood pressure were measured. After correction for possible confounders, model fitting was used to estimate heritability and 95% confidence limits in three age groups of similar size, i.e. 18-29, 30-39 and > or = 40 years. RESULTS: Heritability estimates were significant in each age group, ranging from 35 to 67% for the various blood pressure measurements. The estimates tended to decrease with increasing age, except for conventional diastolic blood pressure, but the intergroup differences did not reach statistical significance, despite adequate power. CONCLUSIONS: In conclusion, blood pressure heritability is significant in various age groups, but does not substantially change with advancing age. Twin analysis does not indicate that models for blood pressure regulation in various age groups should take into account the possibility of age-related changes in the expression of relevant genes, in the presence of relevant environmental agents, or in the susceptibility to the latter (gene-environment interaction). |
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Authors:
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W J Vinck; R H Fagard; R Loos; R Vlietinck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Journal of hypertension Volume: 19 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1007-13 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium. Wouter.Vinck@med.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Analysis of Variance Biometry Blood Pressure / genetics* Blood Pressure Monitoring, Ambulatory Environment Female Humans Male Middle Aged Models, Cardiovascular Twins, Dizygotic / genetics Twins, Monozygotic / genetics |
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