Document Detail

The impact of gender on vessel size in patients with angiographically normal coronary arteries.
MedLine Citation:
PMID:  16881982     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Female gender has been associated with worse clinical outcomes following coronary revascularization. Whether a gender-specific difference in vessel size is contributing to this finding remains controversial. We sought to better define the relationship between gender and coronary artery size. METHODS: Baseline characteristics were obtained and quantitative coronary angiography was performed on 145 consecutive patients with angiographically normal (smooth luminal surface with no evidence of any irregularity in the coronary tree) coronary arteries. Two separate orthogonal measurements each were taken of the left main, proximal left anterior descending, proximal circumflex, proximal right coronary artery, and ostial posterior descending arteries. An average coronary size, derived from five separate coronary artery measurements, was tabulated for each patient. RESULTS: After correcting for confounding variables, including BSA, height, diabetes, and left ventricular hypertrophy using multivariate linear regression, female gender remained a strong independent predictor of coronary vessel size (Beta =-0.30, P = 0.004). Female gender was associated with a 0.30 mm decrease in average coronary size. CONCLUSION: Gender is a strong, independent predictor of coronary artery size even when taking into account differences in body size. This difference may contribute to worse outcomes of women undergoing coronary revascularization.
Felix Yang; Robert M Minutello; Sherrita Bhagan; Atul Sharma; S Chiu Wong
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  19     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-10-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  340-4     Citation Subset:  IM    
Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA.
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MeSH Terms
Chest Pain / epidemiology,  radiography
Confounding Factors (Epidemiology)
Coronary Angiography*
Coronary Artery Disease / epidemiology,  pathology,  radiography
Coronary Vessels / anatomy & histology*
Linear Models
Middle Aged
Predictive Value of Tests
Sex Characteristics*
Sex Distribution
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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