| The impact of gender on urine C-peptide creatinine ratio interpretation. | |
| | |
MedLine Citation:
|
PMID: 22568974 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Urinary C-peptide creatinine ratio (UCPCR) is a non-invasive and convenient way of assessing endogenous insulin production. Adjusting for urine creatinine levels allows for differences in urine concentration. Creatinine excretion is known to be higher in men due to gender differences in muscle mass. We investigated the impact of gender on UCPCR. METHODS: One hundred and seventy-six subjects underwent a mixed meal tolerance test (MMTT). We looked at the relationship between UCPCR on urine C-peptide and creatinine excretion rates using timed post-meal urine samples. A further 415 subjects had two-hour post-meal UCPCR measurements in order to derive gender-specific percentiles for different diabetes subgroups and controls. RESULTS: UCPCR was 1.48-fold higher in women (n = 78) than men (n = 98), median (interquartile range [IQR]): 1.88 (0.49-3.49) men versus 2.88 (1.58-4.91) nmol mmol(-1) women, P = 0.01. This reflects a gender difference in creatinine excretion rates (11.5 [8.3-13.7] men versus 8.2 [5.6-9.1] women μmol min(-1) P < 0.001). C-peptide excretion rate was similar in men and women (19.8 [5.2-37.0] versus 22.1 [7.4-40.5] pmol min(-1), P = 0.7). UCPCR was higher in women in all subgroups defined by diabetes classification and treatment, except long-term type 1 diabetes in whom C-peptide secretion was minimal. CONCLUSIONS: Gender affects UCPCR, with higher values found in women. This results from lower urine creatinine reflecting gender differences in muscle mass. This necessitates gender-specific ranges for accurate interpretation of UCPCR results. |
| | |
Authors:
|
Nicholas J Thomas; Beverley M Shields; Rachel E J Besser; Angus G Jones; Andrew Rawlingson; Emily Goodchild; Christopher Leighton; Pamela Bowman; Maggie Shepherd; Bridget A Knight; Timothy J McDonald; Andrew T Hattersley |
Related Documents
:
|
11270664 - The sexual games of the body politic: fantasy and state violence in northern ireland. 3340024 - Assessing women's health needs. 22291484 - Pharmacologic agents for smoking cessation: a clinical review. 22458794 - Risk factors in motorcyclist fatalities in taiwan. 12383984 - Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast can... 20524054 - Hormonal exposures and the risk of uveal melanoma. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-5-8 |
Journal Detail:
|
Title: Annals of clinical biochemistry Volume: - ISSN: 1758-1001 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Royal Devon and Exeter NHS Foundation Trust. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Magneto-conductance fingerprints of purely quantum states in the open quantum dot limit.
Next Document: The use of trypsin to confirm the presence of macrocreatine kinase on isoenzyme electrophoresis.