Document Detail

The impact of gender difference on the effects of preinfarction angina on microvascular damage with reperfused myocardial infarction.
MedLine Citation:
PMID:  20641118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have addressed gender differences in evoking preconditioning. In an experimental study, it was reported that the preconditioning effect disappeared after gonadectomy. OBJECTIVES: We sought to determine the effects of preinfarction angina (PA) on myocardial damage using intravenous contrast echocardiography. METHODS: We studied 334 consecutive patients with anterior myocardial infarction (AMI) who underwent successful angioplasty. All patients underwent myocardial contrast echocardiography (MCE) 14 days after percutaneous coronary intervention (PCI). Contrast defect was calculated as contrast defect area/myocardial area. Typical angina occurring in the 24-hour period preceding myocardial infarction was present in 133 patients (29 women) (group PA) and absent in 201 patients (43 women) (group non-PA). All women were postmenopausal. RESULTS: The contrast defect size and peak creatinine phosphokinase (max CPK) level in women were both significantly higher than that of men in group PA (18.3% +/- 6.3% vs 11.9% +/- 9.0%; P < 0.01 and 5000 +/- 599 IU/L vs 2672 +/- 221 IU/L; P < 0.005). The functional status of the myocardium among group PA, as expressed by risk area wall motion score index, was better in men than in women at 14 days (1.1 +/- 0.8 vs 1.7 +/- 0.8; P < 0.01) and at 6 months (0.7 +/- 0.4 vs 1.6 +/- 0.6; P < 0.01). However there were no significant gender differences in group non-PA. Multivariate regression analysis showed that the female gender (P < 0.05) was a significant independent predictor for microvascular damage. CONCLUSIONS: These findings suggest that preconditioning effects were attenuated in women with reperfused AMI.
Shinobu Hosokawa; Yoshikazu Hiasa; Naotsugu Murakami; Yohei Tobbeto; Takafumi Nakagawa; Pomin Chen; Shin-Ichiro Miyazaki; Riyo Ogura; Keitaro Mahara; Hitoshi Miyajima; Kenichiro Yuba; Takefumi Takahashi; Koichi Kishi; Ryuji Ohtani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  33     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Wiley Periodicals, Inc.
Division of Cardiology, Tokushima Red Cross Hospital, Tokushima, Japan.
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MeSH Terms
Aged, 80 and over
Angina Pectoris / diagnosis,  etiology*,  physiopathology
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*
Biological Markers / blood
Chi-Square Distribution
Contrast Media / diagnostic use
Coronary Angiography
Coronary Circulation*
Creatine Kinase / blood
Echocardiography, Doppler
Middle Aged
Myocardial Contraction
Myocardial Infarction / complications,  diagnosis,  physiopathology,  therapy*
Myocardial Reperfusion Injury / diagnosis,  etiology,  physiopathology,  prevention & control*
Myocardium / enzymology,  pathology*
Odds Ratio
Polysaccharides / diagnostic use
Recovery of Function
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Time Factors
Treatment Outcome
Ventricular Dysfunction, Left / etiology,  physiopathology,  prevention & control
Reg. No./Substance:
0/Biological Markers; 0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508; EC Kinase

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