Document Detail


The impact of food contaminants on the bioavailability of trace metals.
MedLine Citation:
PMID:  12437148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organic solvents, detergents, organochloric compounds, pesticides, mycotoxins, residues of veterinary drugs and metals are examples for food contaminants; they are usually present at very low concentrations. Their impact on absorption and distribution kinetics of essential trace metals, if there is any, can be mediated by three types of mechanisms: 1. In animal experiments, contaminants like T-2 mycotoxins or 2,3,7,8 tetrachlorodibenzodioxin inhibited absorptive or excretory mechanisms at high concentrations which, however, are usually not found in food. 2. Food contaminants with metal binding properties can interact with essential metals in the intestinal lumen or during transfer through the intestinal mucosa and affect their absorption according to the rules of complex chemistry. To balance the effect of endogenous metal-binding food constituents, they should be present in comparably high quantities. Usually, however, the concentration of contaminants is approx. 6 orders of magnitude lower than that of endogenous food ligands. 3. Contaminating metals may interfere with the regulated absorption, distribution, and excretion kinetics of essential metals. Such mechanisms may be amplified by vicious cycles. In general, however, food contaminations with metals are too low to have an impact on the bioavailability of essential metals.
Authors:
Klaus Schümann; Bernd Elsenhans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  16     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-19     Completed Date:  2003-06-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Affiliation:
Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, München, Germany. K.Schuemann@lrz.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadmium / metabolism
Edetic Acid / pharmacology
Food Contamination* / prevention & control
Humans
Intestinal Mucosa / pathology
Iron / metabolism
Kinetics
Lead / pharmacology
Ligands
Mercury / pharmacology
Metals / adverse effects*,  metabolism
Mucous Membrane / metabolism
Risk
Trace Elements
Zinc / metabolism
Chemical
Reg. No./Substance:
0/Ligands; 0/Metals; 0/Trace Elements; 60-00-4/Edetic Acid; 7439-89-6/Iron; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-43-9/Cadmium; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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