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The impact of feeding interval on feeding outcomes in very low birth-weight infants.
MedLine Citation:
PMID:  21252961     Owner:  NLM     Status:  Publisher    
Objective:Test the hypothesis that very low birth-weight (VLBW) infants fed every 2 h (q2) are able to reach full enteral feedings more quickly than infants fed every 3 h (q3).Study Design:We performed a retrospective cohort study comparing q2 infants (n=103) with q3 infants (n=251). The primary outcome was days from start of a feeding advance to full feedings (120 ml per kg per day). Multivariable regression models were used to control for maternal and perinatal factors that preceded the initiation of the feeding advance.Result:Infants fed q2 reached full feedings 2.7 days sooner than q3 infants (95% confidence interval (CI) 1.5, 3.9). After adjustment for confounders, q2 infants reached full feedings 3.7 (95% CI 1.6, 5.9) days more quickly. Infants fed q3 were more likely to receive >28 days of parenteral nutrition (odds ratio (OR) 4.7; 95% CI 1.5, 14.4), and were more likely to have feeds held for 7 days (OR 4.7, 95% CI 1.9, 11.7).Conclusion:VLBW infants demonstrate improved feeding tolerance when fed more frequently.Journal of Perinatology advance online publication, 20 January 2011; doi:10.1038/jp.2010.153.
S B Demauro; S Abbasi; S Lorch
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
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