| The impact of the extracellular matrix on inflammation. | |
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MedLine Citation:
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PMID: 20865019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The advent of in situ immunology and intravital analyses of leukocyte movement in tissues has drawn attention to the previously neglected extracellular matrix (ECM) and its role in modulating immune cell behaviour in inflamed tissues. The ECM exists in different biochemical and structural forms; both their individual components and three-dimensional ultrastructure impart specific signals to cells that modulate basic functions that are important for the early steps in inflammation, such as immune cell migration into inflamed tissues and immune cell differentiation. In chronically inflamed tissues, aberrant ECM expression and fragments of the ECM that are derived from tissue-remodelling processes can influence immune cell activation and survival, thereby actively contributing to immune responses at these sites. |
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Authors:
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Lydia Sorokin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 10 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 712-23 Citation Subset: IM |
Affiliation:
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Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany. sorokin@uni-muenster.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Extracellular Matrix / immunology* Humans Inflammation / immunology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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