Document Detail


The impact of extensive medial frontal lobe damage on 'Theory of Mind' and cognition.
MedLine Citation:
PMID:  14998913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of humans to predict and explain other people's behaviour by attributing to them independent mental states, such as desires and beliefs, is considered to be due to our ability to construct a 'Theory of Mind'. Recently, several neuroimaging studies have implicated the medial frontal lobes as playing a critical role in a dedicated 'mentalizing' or 'Theory of Mind' network in human brains. Here, we report a patient, G.T., who suffered an exceptionally rare form of stroke-bilateral anterior cerebral artery infarction, without rupture or the complications associated with anterior communicating artery aneurysms. Detailed high-resolution neuroanatomical investigations revealed extensive damage to the medial frontal lobes bilaterally, including regions identified to be critical for 'Theory of Mind' by functional neuroimaging of healthy human subjects. For the first time in such a patient, we carried out a thorough assessment of her cognitive profile including, critically, an experimental investigation of her performance on a range of tests of 'Theory of Mind'. G.T. had a dysexecutive syndrome characterized by impairments in planning and memory, as well as a tendency to confabulate. Importantly, however, she did not have any significant impairment on tasks probing her ability to construct a 'Theory of Mind', demonstrating that the extensive medial frontal regions destroyed by her stroke are not necessary for this function. These findings have important implications for the functional anatomy of 'Theory of Mind', as well as our understanding of medial frontal function. Possible reasons for the discrepancies between our results and neuroimaging studies are discussed. We conclude that our findings urge caution against using functional imaging as the sole method of establishing cognitive neuroanatomy.
Authors:
Chris M Bird; Fulvia Castelli; Omar Malik; Uta Frith; Masud Husain
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-03-03
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  127     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  914-28     Citation Subset:  AIM; IM    
Affiliation:
Institute of Cognitive Neuroscience, University College London, London, UK. chris.bird@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Cognition Disorders / etiology*
Female
Frontal Lobe / physiopathology*
Humans
Infarction, Anterior Cerebral Artery / physiopathology,  psychology*
Middle Aged
Models, Psychological
Neuropsychological Tests
Social Behavior*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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