| The impact of exposure variables on the induction of skin sensitization. | |
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MedLine Citation:
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PMID: 16918618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whereas many investigations of the variables associated with the elicitation of allergic contact dermatitis have been undertaken, to the point where we can begin to predict the likelihood of elicitation occurring in a given situation, the same is not true for the induction of skin sensitization. Studies have demonstrated that increasing dose has an impact; in an experimental setting, a number of variables received attention some decades ago. However, in the work reported here, the relative importance of the frequency and the duration of exposure is highlighted. In an investigation using a human repeated insult patch test, it was demonstrated that reduction of the exposure duration from 48 hr to 5 min decreased the rate of sensitization to 1% p-phenylenediamine (PPD) from 54% to 3%. However, in an extended clinical study, it was observed that infrequent but longer duration and higher concentration exposure to PPD was significantly less likely to induce sensitization compared to more frequent, short duration, and lower concentration exposure. Detailed statistical analysis of the results indicated that the most important factor driving the induction of skin sensitization was the number of exposures. |
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Authors:
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David A Basketter; Donna Jefferies; Bob J Safford; Nicola J Gilmour; Ian R Jowsey; John McFadden; Wannisa Chansinghakul; Imelda Duangdeeden; Preya Kullavanijaya |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Contact dermatitis Volume: 55 ISSN: 0105-1873 ISO Abbreviation: Contact Derm. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: Denmark |
Other Details:
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Languages: eng Pagination: 178-85 Citation Subset: IM |
Affiliation:
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Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedfordshire MK44 1PR, UK. david.basketter@unilever.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / administration & dosage, diagnostic use* Dermatitis, Allergic Contact / diagnosis*, etiology, pathology Dose-Response Relationship, Drug Female Humans Male Middle Aged Patch Tests / standards* Phenylenediamines / administration & dosage, diagnostic use* Reference Values Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Phenylenediamines; 106-50-3/4-phenylenediamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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