Document Detail


The impact of expansive arterial remodeling on clinical presentation in carotid artery disease: a multidetector CT angiography study.
MedLine Citation:
PMID:  17569959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Atherosclerotic arterial remodeling has been described in the coronary circulation but has not been studied extensively for carotid atherosclerosis. The purpose of our study was to examine the association between carotid artery remodeling and clinical presentation in patients with significant stenosis by using multidetector row CT (MDCT).
MATERIALS AND METHODS: One hundred eight patients with >or=50% stenosis (North American Symptomatic Carotid Endarterectomy Trial criteria) by MDCT angiography between January 2004 and June 2006 were identified. The study group included 37 symptomatic (65.9 +/- 13.0 years; 12 women; stenosis, 81.5 +/- 12.2%; 17 with stroke; 15 with transient ischemic attack; 5 with amaurosis fugax) and 71 asymptomatic patients (70.5 +/- 10.5 years; 28 women; stenosis, 78.8 +/- 11.1%). Remodeling ratio (RR) was calculated by dividing the outer vessel circumference at the site of greatest stenosis by a normal reference-segment vessel circumference. Maximum vessel thickness (MxVT) and eccentricity index (EI) of the plaque, defined as maximal thickness/minimal thickness at the site of greatest luminal narrowing, were also determined. Data were analyzed by using an independent t test.
RESULTS: The RR was significantly higher in symptomatic patients (1.64 +/- 0.44) than in asymptomatic patients (1.41 +/- 0.5) (P=.02). There was no significant difference in MxVT in symptomatic (5.9 +/- 2.1 mm) and asymptomatic patients (5.6 +/- 2.4 mm) (P=.45) and no significant difference in EI (symptomatic, 4.7 +/- 2.7; asymptomatic, 4.3 +/- 2.2; P=.38).
CONCLUSION: In this series of subjects with significant internal carotid artery stenosis, expansive carotid remodeling was significantly greater in patients with cerebral ischemic symptoms than in asymptomatic patients. The extent of expansive remodeling may indicate underlying atherosclerotic plaque vulnerability. MDCT has a role in the evaluation of carotid artery disease beyond examining luminal stenosis.
Authors:
A D Hardie; C M Kramer; P Raghavan; E Baskurt; K R Nandalur
Related Documents :
1192359 - Delayed cerebrovascular consequences of therapeutic radiation. a clinicopathologic stud...
2401909 - Small aneurysm clips for surgery of neck vessels.
2548789 - Doppler and duplex sonography of the cervical arteries and correlations with other exam...
7423579 - Angiographic appearance of carotid occlusion in acute stroke.
11977909 - Extracranial internal carotid artery occlusion: the role of common carotid artery volum...
19120549 - Arterial stiffness is associated with raised levels of the inflammatory marker erythroc...
20399319 - Silent pulmonary embolism in patients with deep venous thrombosis: a systematic review.
9191609 - Decreased nitric oxide production accounts for secondary arteriolar constriction after ...
10102349 - Use of omentum pedicled graft to protect great vessels in gastric transposition for pha...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  28     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1067-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Carotid Artery Diseases / radiography*
Cerebral Angiography / instrumentation,  methods*
Female
Humans
Male
Radiographic Image Enhancement / instrumentation,  methods
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
R01 HL075792/HL/NHLBI NIH HHS; R01 HL075792-03/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CT and ultrasound in the study of ulcerated carotid plaque compared with surgical results: potential...
Next Document:  Multivoxel proton MR spectroscopy in malformations of cortical development.