| The impact of endothelin-1 genetic analysis and job strain on ambulatory blood pressure. | |
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MedLine Citation:
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PMID: 21767690 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: An interaction between the endothelin-1 gene (EDN1), blood pressure (BP) and social determinants has been previously found. Using a well-characterized cohort of participants, the impact of associations between genetic factors and job strain on BP was evaluated. METHODS: A cross-sectional analysis of five polymorphisms covering the EDN1, of which 2 were previously reported to be associated with BP, was performed. Study subjects had previously completed a baseline evaluation including 24-h ambulatory BP monitoring and an assessment of job strain. This report presents the findings for 184 subjects who gave DNA samples for genetic analysis. One-way analysis of variance (ANOVA) was performed between each genetic marker and 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as two-way ANOVAs to test the interaction effect with job strain. RESULTS: Trends for relationships were observed between SBP and two polymorphisms: rs10478694 and rs5369. An interaction between job strain and those heterozygous for two polymorphisms showed higher SBP (P=.029 and .008) and a tendency for higher DBP. All findings were more significant when analyses were confined to the 139 Caucasian subjects. CONCLUSION: This is the first study to report an interaction between the EDN1 gene, job strain and BP, supporting previous evidence of a role of this gene in the interaction between environmental stress and ambulatory BP. Given the limited sample size, the results should be considered preliminary, and further studies are required. |
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Authors:
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Sheldon W Tobe; Brian Baker; Katie Hunter; Alex Kiss; Nancy Perkins; Lissette Gomez; Yu Feng; Karen Wigg; Cathy L Barr |
Publication Detail:
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Type: Journal Article Date: 2011-03-15 |
Journal Detail:
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Title: Journal of psychosomatic research Volume: 71 ISSN: 1879-1360 ISO Abbreviation: J Psychosom Res Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: England |
Other Details:
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Languages: eng Pagination: 97-101 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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