| The impact of dialysis type on biomarkers for cardiovascular diseases. | |
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MedLine Citation:
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PMID: 21918314 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: The impact of dialysis type on the biomarkers that reflect the severity of cardiovascular diseases is not clearly known. We aimed to investigate the effect of dialysis type on biomarkers of cardiovascular diseases in patients with end-stage renal disease (ESRD). STUDY DESIGN: The study included 108 patients who had been on dialysis treatment (57 patients receiving hemodialysis, 51 patients receiving peritoneal dialysis) for ESRD for at least three months. Blood samples were collected just after the dialysis. Serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), cardiac troponin I (TnI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and plasma fibrinogen levels were measured and compared between the two dialysis groups. RESULTS: The two dialysis groups were similar with respect to age and gender. The frequency of hypertension was significantly higher in patients receiving peritoneal dialysis. This group also had higher total cholesterol, HDL cholesterol, LDL cholesterol, and hemoglobin levels. Serum levels of NT-proBNP, hs-CRP, IL-6, and TNF-α, and plasma fibrinogen levels were similar in the two dialysis groups (p>0.05), but TnI was significantly higher in patients receiving peritoneal dialysis (p=0.04). Comparison of the patient subgroups based on the duration of dialysis (<12 months, 12-36 months, and >36 months) showed that longer dialysis duration was associated with significantly lower values of NT-proBNP, TNF-α, and hs-CRP (p<0.05). CONCLUSION: The dialysis type does not affect serum NT-proBNP, hs-CRP, IL-6, TNF-α, and plasma fibrinogen levels, but TnI level is higher in patients treated with peritoneal dialysis. |
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Authors:
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Asife Sahinarslan; Galip Güz; Rüya Mutluay; Kaan Okyay; Canan Demirtaş; Hatice Paşaoğlu; Rıdvan Yalçın |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır Volume: 39 ISSN: 1016-5169 ISO Abbreviation: Turk Kardiyol Dern Ars Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426239 Medline TA: Turk Kardiyol Dern Ars Country: Turkey |
Other Details:
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Languages: eng Pagination: 456-62 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medicine Faculty of Gazi University, Ankara, Turkey. asifesah@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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