| The impact of diabetic retinopathy and diabetic macular oedema on health-related quality of life in Type 1 and Type 2 diabetes. | |
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MedLine Citation:
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PMID: 22205611 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose:To assess the impact of diabetic retinopathy (DR), and diabetic macular oedema (DME) on health-related quality of life (HRQoL) in Type 1 and Type 2 diabetes using the EuroQoL EQ-5D generic multi-attribute utility instrument (MAUI).Methods:In this cross-sectional study, 577 patients with diabetes were recruited from specialized eye clinics in Melbourne. Each patient underwent clinical, biochemical and anthropometric assessments. The severity of combined DR and DME (no DR/DME; mild NPDR [non-proliferative DR] and/or mild DME; moderate NPDR and/or moderate DME; and vision-threatening DR (VTDR) (severe NPDR or PDR [proliferative DR] and/or severe DME)) in the worse eye was calculated. EQ-5D utilities were the main outcome. As the distribution of the utilities was skewed, independent associations were explored using multivariable quantile regression models (five quintiles, namely 15(th), 30(th), 45(th), 60(th), 75(th)) ranging from poorest to highest HRQoL.Results:Participants' median age was 66 years (range: 26-90). Of the 577 participants, 223 (38.7%) had no DR/DME; 35 (6.1%) had mild NPDR/DME; 127 (22.0%) moderate NPDR/DME; and 192 (33.3%) had VTDR. In adjusted models, neither presence nor severity of DR/DME was significantly associated with any quantile of the EQ-5D. In contrast, the presence of diabetic complications (other than DR) (β=-0.153 se=0.052, p<0.001), other non-ocular comorbidities (β=-0.115, se=0.038, p<0.01) and higher body mass index (β=-0.007, se=0.002, p<0.001) were all associated with worse HRQoL.Conclusions:Using a generic MAUI, the EQ-5D, we found that presence or severity of DR/DME and associated vision loss were not associated with any quantile of HRQoL. Our findings suggest that the EQ-5D lacks sensitivity in assessing the impact of the severity of DR/DME on HRQoL parameters and that condition-specific instruments may better capture the full impact of the association. |
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Authors:
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Eva K Fenwick; Jing Xie; Julie Ratcliffe; Konrad Pesudovs; Robert P Finger; Tien Y Wong; Ecosse L Lamoureux |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Eye Research Australia, University of Melbourne, the Royal Victorian Eye and Ear Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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