Document Detail

The impact of dental surgery on HSV-1 reactivation in the oral mucosa of seropositive patients.
MedLine Citation:
PMID:  17954324     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Herpes simplex virus type 1 (HSV-1) is a member of the human herpes virus family. Most of the population (90%) has antibodies to HSV-1, and as many as 40% of these individuals may develop secondary herpes. Shedding of HSV-1 in the oral mucosa can be induced by many factors, including stress, sunlight, menstruation, and physical trauma. The aim of the present study was to evaluate the impact of dental surgical procedures on HSV-1 shedding in the oral mucosa. PATIENTS AND METHODS: The case group comprised 48 patients undergoing third molar extraction (case group) and 48 patients undergoing conventional restorative procedures (control group). All of the patients were IgG-positive for HSV-1. Oral swabs were performed before and 1 week after the procedures to investigate HSV-1 reactivation by nested polymerase chain reaction. RESULTS: The frequency of positive oral swabs to HSV-1 in the group that underwent surgery (4.2%) was not statistically different from that in the control group (2.1%). CONCLUSIONS: The results indicate that oral surgical trauma does not have a significant impact on HSV-1 shedding in the oral mucosa.
Luciano Marques-Silva; Wagner Henriques Castro; Eliane Lustosa Cabral Gomez; André Luiz Sena Guimarães; Marina Sena Lopes Silva; Ricardo Santiago Gomez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  65     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2269-72     Citation Subset:  AIM; D; IM    
Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
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MeSH Terms
Antibodies, Viral / blood
DNA, Viral / analysis
Dental Restoration, Permanent*
Electrophoresis, Agar Gel
Follow-Up Studies
Herpes Labialis / virology
Herpesvirus 1, Human / immunology,  physiology*
Immunoglobulin G / blood
Molar, Third / surgery
Mouth Mucosa / virology*
Polymerase Chain Reaction
Stomatitis, Herpetic / virology*
Tooth Extraction*
Tooth, Impacted / surgery
Virus Activation / physiology*
Virus Shedding / physiology
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulin G

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