| The impact of cataract on the quantitative, non-invasive assessment of retinal blood Flow. | |
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MedLine Citation:
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PMID: 21955552 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: The aim of the study was to determine the impact of cataract on the quantitative, non-invasive assessment of retinal blood flow assessed by bidirectional laser Doppler flowmetry and simultaneous vessel densitometry. Methodology: Ten patients scheduled for extracapsular cataract extraction using phacoemulsification and intraocular lens implantation between the ages of 61 and 84 (mean age 73 years, SD ± 8) were prospectively recruited. Two visits were required to complete the study; one visit prior to extracapsular cataract extraction and one at least 6 weeks after the surgery to allow for sufficient postoperative recovery. The severity of cataract was documented using the Lens Opacity Classification System (LOCS, III) at the first visit. Retinal arteriolar hemodynamics were measured at both visits using the high-intensity setting of the Canon Laser Blood Flowmeter. Results: All eyes showed no clinical signs of postoperative intraocular inflammation. The quantitative assessment of retinal arteriolar diameter and blood flow were reduced following extracapsular cataract extraction (Wilcoxon signed-rank test, p = 0.022 and p = 0.028, respectively); however, centreline blood velocity was not significantly changed (Wilcoxon signed-rank test, p = 0.074). Intraocular pressure was unchanged pre- and postcataract extraction. Conclusions: Retinal vessel densitometry assessment in the presence of cataract results in the erroneous elevation of the diameter measurement and thereby the calculation of blood flow. The bidirectional Doppler assessment of blood velocity appears to be more robust to light scatter induced by cataract. Care needs to be exercised in the interpretation of studies of retinal vessel diameter or blood flow that utilize similar densitometry techniques. |
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Authors:
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Behrooz Azizi; Tien Wong; Jennifer Wan; Shaun Singer; Chris Hudson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-28 |
Journal Detail:
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Title: Acta ophthalmologica Volume: - ISSN: 1755-3768 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation. |
Affiliation:
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Retina Research Group, Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada Retina Research Group, School of Optometry, University of Waterloo, Waterloo, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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