Document Detail

The impact of butyric acid on the cardiovascular system.
MedLine Citation:
PMID:  3677720     Owner:  NLM     Status:  MEDLINE    
The influence of sodium salt of butyric acid (C4H7NaO2) on the functional state of the cardiovascular system was studied on 12 guinea-pigs and 15 rabbits by the thermodilution method. The following parameters were determined: cardiac output (CO), arterial blood pressure (AP), total peripheral vascular resistance (TPVR), and in rabbits the heart rate (HR). It was found that butyric acid induces significant changes in TPVR, which correlate with changes in CO and AP. These changes could to a considerable extent be prevented by the administration of indomethacin. Haemodynamic changes induced by butyric acid are primarily connected with changes in vascular tonus, induced by the action of F2 alpha prostaglandins whose synthesis is intensified by the influence of butyric acid.
A Kristev; D Mitkov; Y Lukanov
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  29     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
Department of Pathophysiology, I. P. Pavlov Medical Institute, Plovdiv, Bulgaria.
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MeSH Terms
Blood Pressure / drug effects
Butyrates / pharmacology*
Butyric Acid
Butyric Acids / pharmacology*
Cardiac Output / drug effects
Guinea Pigs
Heart Rate / drug effects
Hemodynamics / drug effects*
Indomethacin / pharmacology
Prostaglandins F / biosynthesis
Vascular Resistance / drug effects
Reg. No./Substance:
0/Butyrates; 0/Butyric Acids; 0/Prostaglandins F; 107-92-6/Butyric Acid; 53-86-1/Indomethacin

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