Document Detail


The impact of breathing pattern and lung size on the alcohol breath test.
MedLine Citation:
PMID:  17171302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Highly soluble gases exchange primarily with the bronchial circulation through pulmonary airway tissue. Because of this airway exchange, the assumption that end-exhaled alcohol concentration (EEAC) is equal to alveolar alcohol concentration (AAC) cannot be true. During exhalation, breath alcohol concentration (BrAC) decreases due to uptake of ethanol by the airway tissue. It is therefore impossible to deliver alveolar gas to the mouth during a single exhalation without losing alcohol to the airway mucosa. A consequence of airway alcohol exchange is that EEAC is always less than AAC. In this study, we use a mathematical model of the human lung to determine the influence of subject lung size on the relative reduction of BrAC from AAC. We find that failure to inspire a full inspiration reduces the BrAC at full exhalation, but increases the BrAC at minimum exhalation. In addition, a reduced inhaled volume and can lead to an inability to provide an adequate breath volume. We conclude that alcohol exchange with the airways during the single-exhalation breath test is dependent on lung size of the subject with a bias against subjects with smaller lung size.
Authors:
Michael P Hlastala; Joseph C Anderson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-14
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  35     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-03-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-72     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Washington, Box 356522, Seattle, WA 98195-6522, USA. hlastala@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Artifacts
Breath Tests / methods*
Computer Simulation
Ethanol / analysis*,  metabolism
Lung / anatomy & histology*,  physiology*
Models, Biological*
Organ Size / physiology
Reproducibility of Results
Respiratory Mechanics / physiology*
Sensitivity and Specificity
Tidal Volume / physiology*
Grant Support
ID/Acronym/Agency:
HL073598/HL/NHLBI NIH HHS; HL24163/HL/NHLBI NIH HHS; T32 EB001650/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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