| The impact of breathing pattern and lung size on the alcohol breath test. | |
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MedLine Citation:
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PMID: 17171302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Highly soluble gases exchange primarily with the bronchial circulation through pulmonary airway tissue. Because of this airway exchange, the assumption that end-exhaled alcohol concentration (EEAC) is equal to alveolar alcohol concentration (AAC) cannot be true. During exhalation, breath alcohol concentration (BrAC) decreases due to uptake of ethanol by the airway tissue. It is therefore impossible to deliver alveolar gas to the mouth during a single exhalation without losing alcohol to the airway mucosa. A consequence of airway alcohol exchange is that EEAC is always less than AAC. In this study, we use a mathematical model of the human lung to determine the influence of subject lung size on the relative reduction of BrAC from AAC. We find that failure to inspire a full inspiration reduces the BrAC at full exhalation, but increases the BrAC at minimum exhalation. In addition, a reduced inhaled volume and can lead to an inability to provide an adequate breath volume. We conclude that alcohol exchange with the airways during the single-exhalation breath test is dependent on lung size of the subject with a bias against subjects with smaller lung size. |
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Authors:
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Michael P Hlastala; Joseph C Anderson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-12-14 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 35 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-03-20 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 264-72 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Washington, Box 356522, Seattle, WA 98195-6522, USA. hlastala@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Breath Tests / methods* Computer Simulation Ethanol / analysis*, metabolism Lung / anatomy & histology*, physiology* Models, Biological* Organ Size / physiology Reproducibility of Results Respiratory Mechanics / physiology* Sensitivity and Specificity Tidal Volume / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL073598/HL/NHLBI NIH HHS; HL24163/HL/NHLBI NIH HHS; T32 EB001650/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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