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The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study.
MedLine Citation:
PMID:  23154192     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction For years, body mass index (BMI) has been used by scientists to track weight problems and obesity in children and adults. Recent studies have implicated the fat mass and obesity gene (FTO) in the increase of BMI in young adults. A longer duration of breastfeeding is known to reduce the risk of being overweight later in life, but its ability to modify the effect because of FTO is not known. METHODS: We studied 1096 children from the Western Australian Pregnancy (Raine) cohort who were followed up from birth to 14 years of age. Linear mixed-effects models were used to investigate BMI growth trajectories in boys and girls separately. RESULTS: An association was found between BMI growth and the duration of exclusive breastfeeding (EXBF) among carriers of the risk allele of the FTO SNP rs9939609. In girls, EXBF interacts with the SNP at baseline and can reverse the increase in BMI because of SNP risk allele by age 14 years after 3 months of EXBF. In boys, EXBF reduces BMI both in carriers and non-carriers of the risk allele with an association found after 10 years of age. Six months of EXBF will put the boys' BMI growth curves back to the normal range. CONCLUSIONS: Our study could have major health implications by providing new perspectives for the prevention of growth problems in children carrying risk alleles in the FTO gene.
Authors:
Taraneh Abarin; Yan Yan Wu; Nicole Warrington; Stephen Lye; Craig Pennell; Laurent Briollais
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  International journal of epidemiology     Volume:  -     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, School of Women's and Infants' Health, University of Western Australia, Crawley, Australia and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
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