Document Detail


The impact of body mass index on the development of systemic inflammatory response syndrome and sepsis in patients with polytrauma.
MedLine Citation:
PMID:  23260868     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Obesity is a growing problem in industrial nations. Our aim was to examine how overweight patients coped with systemic inflammatory response syndrome (SIRS) after polytrauma. METHODS: A total of 651 patients were included in this retrospective study, with an ISS≥16 and age≥16 years. The sample was subdivided into three groups: body mass index (BMI; all in kg/m(2))<25, BMI 25-30 and BMI>30, or low, intermediate and high BMI. The SIRS score was measured over 31 days after admission together with measurements of C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT). Data are given as the mean±SEM if not otherwise indicated. Kruskal-Wallis and χ(2) tests were used for statistical analysis and the significance level was set at p<.05. RESULTS: The maximum SIRS score was reached in the low BMI-group at 3.4±0.4, vs. 2.3±0.1 and 2.5±0.2 in the intermediate BMI-group and high BMI-group, respectively (p<.0001). However, the maximum SIRS score was reached earlier in the BMI 25-30 group at 1.8±0.2 days, vs. 3.4±0.4 and 2.5±0.2 days in the BMI<25 and BMI>30 groups, respectively (p<.0001). The incidence of sepsis was significantly higher in the low BMI group at 46.1%, vs. 0.2% and 0% in the BMI 25-30 and BMI>30 groups, respectively (p<.0001). No significant differences in the CRP, IL-6 or PCT levels were found between groups. CONCLUSIONS: A higher BMI seemed to be protective for these patients with polytrauma-associated inflammatory problems.
Authors:
Ladislav Mica; Jindřich Vomela; Marius Keel; Otmar Trentz
Related Documents :
14627968 - Polyester vs. bovine pericardial patching during carotid endarterectomy: early neurolog...
20884678 - Symptomatic internal carotid artery occlusion: a long-term follow-up study.
1955898 - The prognosis of hospital-referred transient ischaemic attacks.
24378248 - Obesity as an independent predictor of outcome after endovascular abdominal aortic aneu...
9043468 - Hypocalcaemia following thyroidectomy for thyrotoxicosis.
23199378 - Retrograde ejaculation following single-level anterior lumbar surgery with or without r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Injury     Volume:  -     ISSN:  1879-0267     ISO Abbreviation:  Injury     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0226040     Medline TA:  Injury     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Trauma Surgery, University Hospital of Zürich, Switzerland. Electronic address: ladislav.mica@usz.ch.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of TEG(®) and RoTEM(®) inter-changeability in trauma patients.
Next Document:  Alpha cells come of age.