Document Detail


The impact of blood pressure on hippocampal glutamate and mnestic function.
MedLine Citation:
PMID:  20463749     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hypertension is associated with an increased risk of cognitive decline, which is generally regarded as a consequence of advanced cerebral atherosclerosis. Many hypertensive patients, however, suffer from cognitive decline long before they have any signs of cerebrovascular disease. Therefore, this study examines direct effects of blood pressure on neurotransmitter status in the hippocampus, a vulnerable cerebral structure relevant for memory consolidation. Absolute glutamate concentration and N-acetylaspartate (NAA) concentration as an alternative marker of neuronal integrity were determined in the hippocampus and the cerebral cortex (anterior cingulate cortex; ACC) by 3-T proton magnetic resonance spectroscopy in 16 probands without any history of cerebrovascular disease. Memory function was tested by the auditory verbal learning test (AVLT) and the rivermead behavioural memory test (RBMT). Arterial stiffness was assessed by augmentation index (AI). Mean arterial pressure showed a significant negative age-adjusted correlation to absolute glutamate concentrations in the hippocampus (R=-0.655, P=0.011), but not in the ACC. There was no significant correlation of mean arterial pressure and NAA in either hippocampus or ACC. AI did not affect hippocampal glutamate. Moreover, there was a significant negative correlation between mean arterial pressure and AVLT (r=-0.558, P=0.025) and RBMT score (r=-0.555, P=0.026). There is an inverse relation between blood pressure and the concentration of hippocampal glutamate. Glutamate is essential for long-term potentiation, the neurobiological correlate for memory formation in the hippocampus. Thus, hypertension-associated cognitive decline may not only be mediated by structural atherosclerotic wall changes, but also by functional changes in neurotransmission.
Authors:
T H Westhoff; F Schubert; C Wirth; M Joppke; A A Klär; W Zidek; J Gallinat
Related Documents :
19804249 - Effects of caffeine and coffee consumption on cardiovascular disease and risk factors.
22288309 - Suspect carbon dioxide embolism during retroperitoneoscopic adrenalectomy.
12107419 - The 2001 canadian recommendations for the management of hypertension: part one--assessm...
9194509 - Is diastolic hypertension an independent risk factor for stroke in the presence of norm...
1630079 - Dietary salt and risk factors for cardiovascular disease.
7100969 - Biocultural risks in longevity: samoans in california.
22245299 - Pressure transmission through ureteric stents: a novel in vivo human study.
24254709 - Hemodynamic response to intravenous adenosine and its effect on fractional flow reserve...
1858989 - Left ventricular performance during propofol or methohexital anesthesia: isotopic and i...
Publication Detail:
Type:  Journal Article     Date:  2010-05-13
Journal Detail:
Title:  Journal of human hypertension     Volume:  25     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenoma...
Next Document:  Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukem...