| The impact of beta-blockers on mortality in stable angina: a meta-analysis. | |
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MedLine Citation:
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PMID: 22555225 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Beta-blockers are recommended as first-line symptomatic treatment for stable angina. However, their impact on mortality outside the context of myocardial infarction is unknown. We performed a meta-analysis of all randomized trials of beta-blockers in stable angina. Medical databases and cardiology journals were searched for relevant randomized clinical trials. The primary outcome was cardiovascular mortality, separately considering trials of beta-blockers versus placebo and beta-blockers versus other antianginals. We conducted a subgroup analysis on cardioselective versus non-cardioselective beta-blockers and calcium channel antagonists versus nitrates. We calculated odds ratios (ORs) and confidence intervals (CIs) using Peto's method. We found no statistically significant evidence that beta-blockers impact on mortality when compared with placebo (OR, 0.42; CI , 0.15-1.21) or other antianginals (OR, 0.98; CI, 0.86-1.10), or all others (OR, 0.97; CI, 0.86-1.09). There was a trend for cardioselective beta-blockers to have a greater improvement in mortality when compared with placebo and to have greater impact than non-calcium channel antagonists. Beta-blockers do not have statistically significant impact on mortality versus placebo or versus other active comparators. The findings exclude a benefit of 15% or greater and a hazard of 10% or greater. The impact of cardioselectivity requires further study. |
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Authors:
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H L Huang; K A A Fox |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scottish medical journal Volume: 57 ISSN: 0036-9330 ISO Abbreviation: Scott Med J Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983335R Medline TA: Scott Med J Country: Scotland |
Other Details:
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Languages: eng Pagination: 69-75 Citation Subset: IM |
Affiliation:
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University of Edinburgh, Edinburgh, Scotland, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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