Document Detail

The impact of asthma on the gastrointestinal tract (GIT).
MedLine Citation:
PMID:  21437046     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The gastrointestinal tract (GIT) of vertebrates is composed of several distinct compartments and glands as well as an extensive mucosal surface. Its primary function is that of chemical and physical digestion of food and the absorption of nutrients; however, due to its continual antigen exposure, the GIT also has an important defensive immunological function. The GIT's immunological participation is facilitated by the mucosa-associated lymphoid tissues, thought to share the mucosal immunological system with the respiratory mucosa-associated lymphoid tissues. As a result of this shared mucosal immunity, it has been hypothesized that bronchial asthma may be able to affect the body's GIT in the same pathophysiological manner as the airways and lungs. Here we discuss the link between bronchial asthma and pathophysiological features in the GIT - including leukocyte influx, goblet cell alterations, fibrosis, and epithelial and villous atrophy.
Warren Antonio Vieira; Etheresia Pretorius
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Publication Detail:
Type:  Journal Article     Date:  2010-09-09
Journal Detail:
Title:  Journal of asthma and allergy     Volume:  3     ISSN:  1178-6965     ISO Abbreviation:  J Asthma Allergy     Publication Date:  2010  
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101543450     Medline TA:  J Asthma Allergy     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  -    
Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
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