Document Detail

The impact of antenatal cocaine use on maternal characteristics and neonatal outcomes.
MedLine Citation:
PMID:  15280134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the risk factors and evaluate maternal and neonatal outcomes associated with antenatal cocaine use. METHODS: This was a retrospective case-control study of 200 cocaine-exposed maternal-neonatal pairs and 200 controls from 1991 to 2000. RESULTS: Cocaine-using mothers tended to be older, African American, multiparous and incarcerated and they utilized less prenatal care. However, 79% of Hispanics abusing cocaine were primarily English speaking. Cocaine use correlated with syphilis (36 vs. 1%, p = 0.000) and premature rupture of membranes (23 vs. 0%, p = 0.000), fetal demise (5 vs. 0%, p = 0.004), preterm delivery (40 vs. 6%, p = 0.000). Cocaine-exposed infants delivered earlier (36 vs. 39 weeks, p = 0.000), had lower birth weights (2660 vs. 3305 g, p = 0.000), more respiratory distress syndrome (14 vs. 4%, p = 0.001), congenital syphilis (12 vs. 1%, p = 0.000) and longer hospital stays (10 vs. 3 days, p = 0.000); 75% were placed in foster care or adoption and 37.5% had neonatal withdrawal syndrome. There was a stronger positive correlation between neonatal withdrawal and maternal urine toxicology (rho = 0.443, p = 0.000) than with neonatal urine screen (rho = 0.278, p = 0.003). CONCLUSION: Cocaine use in pregnancy is associated with acculturation, lack of prenatal care, and significant social and obstetric complications resulting in increased neonatal morbidity secondary to prematurity, congenital infection and withdrawal syndrome.
D Ogunyemi; G E Hernández-Loera
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  15     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2004-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
King Drew Medical Center/UCLA School of Medicine, Los Angeles, CA, USA.
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MeSH Terms
Alcoholism / complications
Birth Weight / drug effects*
Case-Control Studies
Cocaine / poisoning*
Cocaine-Related Disorders / complications
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Linear Models
Logistic Models
Maternal Age
Multivariate Analysis
Pregnancy Outcome
Respiratory Distress Syndrome, Newborn / etiology
Retrospective Studies
Risk Factors
Socioeconomic Factors
Syphilis / etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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