Document Detail

The impact of angiotensin converting enzyme inhibitors on the arterial wall.
MedLine Citation:
PMID:  9546923     Owner:  NLM     Status:  MEDLINE    
There is recent interest in the possibility that angiotensin converting enzyme inhibitors (ACE inhibitors) may reduce the damage inflicted on the arterial wall by common cardiovascular risk factors such as hypertension, hyperlipidaemia and ageing. The efficacy of these drugs in blood pressure reduction is accepted, but whether there is an excess benefit on arterial structure and function, conferred by use of ACE inhibitors over more traditional antihypertensives, is still under debate. There is also evidence in animal models to suggest that ACE inhibition is effective in reduction of arterial damage due to experimental hyperlipidaemia. ACE inhibitors not only reduce the conversion of angiotensin I and angiotensin II, which can interact with the sympathetic nervous system, but also prevent the degradation of bradykinin. This means that ACE inhibitors have several potential mechanisms through which they could suppress intimal hypertrophy and prevent endothelial dysfunction, which is believed to precede arteriosclerosis in man. Although much further work is needed to clarify the mechanism underlying the beneficial effects on the arterial wall of this group of drugs, they do appear to have significant potential in the effort to reduce cardiovascular mortality and morbidity, especially in high risk groups.
A F Lee; A D Struthers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  1     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  1996  
Date Detail:
Created Date:  1998-04-14     Completed Date:  1998-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM    
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
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MeSH Terms
Angiotensin II / physiology
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Endothelium, Vascular / drug effects*
Hyperlipidemias / drug therapy
Hypertension / drug therapy
Sympathetic Nervous System / physiology
Vascular Diseases / etiology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 11128-99-7/Angiotensin II

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