Document Detail

The impact of age and comorbidity on the progression of disability in late-onset sequelae of poliomyelitis.
MedLine Citation:
PMID:  20382282     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the functional course over 5 years in patients aged 45 to 85 years with late-onset sequelae of poliomyelitis (LOSP) and to explore the impact of age and comorbidity. DESIGN: Prospective cohort study with 5 measurements over 5 years. SETTING: University hospital. PARTICIPANTS: Subjects with LOSP (N=168). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: FIM, Medical Outcomes Study 36-Item Short Form health survey for physical functioning subscale (SF-36-PF), walking test, isokinetic quadriceps strength, and cumulative illness rating scale (CIRS) for comorbidity. RESULTS: The FIM score (mean baseline +/- SD, 121+/-4) and SF-36-PF (mean baseline +/- SD, 39.5+/-24) decreased 2.2 and 3.7 points, respectively, over 5 years independent of age. The distance walked in 2 minutes (mean baseline +/- SD, 126.2+/-34m) decreased 4.5m, quadriceps strength (mean baseline +/- SD, 88.0+/-42.2Nm) declined 7Nm (8%), and CIRS (median baseline=6; range, 0-21) increased 1.5 points. A higher CIRS score was correlated with a lower FIM score and faster decrease in the FIM. A longitudinal model of factors associated with the FIM included sex, age, leg strength sum-score, arm strength sum-score, and CIRS score. The interaction of CIRS and leg strength sum-score with follow-up time was significant. A model of factors associated with SF-36-PF included sex, age, leg strength sum-score, and CIRS score. CONCLUSIONS: Despite a reduction in muscle strength, disability increased little in patients with LOSP. Increased age and comorbidity has a negative effect on disability. Comorbidity and the severity of leg paresis affected the course of functional independence but not the course of perceived physical functioning.
Janneke M Stolwijk-Sw?ste; Irene Tersteeg; Anita Beelen; Gustaaf J Lankhorst; Frans Nollet;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  91     ISSN:  1532-821X     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Department of Rehabilitation Medicine, Vrije Universiteit University Medical Center, 1007 MB Amsterdam, The Netherlands.
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MeSH Terms
Age Factors
Aged, 80 and over
Disability Evaluation
Disease Progression
Hospitals, University
Middle Aged
Muscle Strength
Poliomyelitis / physiopathology*
Prospective Studies
Sex Factors
Time Factors
J M Stolwijk-Sw?ste / ; A Beelen / ; F Nollet / ; G J Lankhorst / ; J Dekker / ; G M van Dijk / ; B Post / ; R J de Haan / ; H Speelman /

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