| The impact of Sickle Cell Disease on exercise capacity in children. | |
| | |
MedLine Citation:
|
PMID: 22922408 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
ABSTRACT BACKGROUND: Little is known about pulmonary vascular complications in children with Sickle Cell Disease (SCD). We hypothesised that transfer factor (DLco) may be used as a surrogate for the size of the pulmonary vascular bed, and that pulmonary vascular abnormalities in SCD children may limit exercise capacity. METHODS: 50 stable SCD patients aged10 to-18 years and 50 healthy controls matched for race and age were recruited. Incremental ergometer cardiopulmonary exercise testing (CPET) was performed using respiratory mass spectrometry (RMS) for exhaled gas analysis. A rebreathing manoeuvre was used to measure functional residual capacity (FRC), effective pulmonary blood flow (Qpeff) and DLCO, and helium dilution was used to calculate minute ventilation (VE), oxygen consumption (VO2) and carbon dioxide production (CO2). RESULTS: In the 89 evaluable subjects, there were no ventilatory differences between SCD and controls. Qpeff was consistently 15-20% greater in SCD than controls at all stages but Dlco corrected for both surface area and haemoglobin was only about 7-10% greater in SCD at all stages As a result the Dlco/Qpeff ratio was considerably lower in SCD at all stages. Arteriovenous oxygen content difference was about one third less in SCD at all stages. CONCLUSIONS: Contrary to our hypothesis, failure to maintain a sufficient Qpeff to compensate for anaemia led to exercise limitation. The ratio of Pulmonary capillary blood volume to flow is reduced throughout, implying subtle pulmonary vascular disease; however this was not a factor limiting exercise.1Royal Brompton Hospital, London, United Kingdom.2St Georges' Hospital, London, United Kingdom.Corresponding author's details (also author for reprint requests): Dr Mark Rosenthal, Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3 6NP Email: M. Rosenthal@rbht.nhs.uk. |
| | |
Authors:
|
Rifat A Chaudry12; Andrew Bush1; Mark Rosenthal1; Suzanne Crowley2 |
Related Documents
:
|
6357288 - Emg biofeedback for functional bladder-sphincter dyssynergia: a case study. 862208 - Normal excretion of vasopressin and the effect of everyday activity. 23497658 - Use of positive expiratory pressure during six minute walk test: results in patients wi... 23099448 - Evidence of vascular endothelial dysfunction in young patients with cystic fibrosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
|
Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extracorporeal photopheresis in 62 patients with acute and chronic GVHD: Results of treatment with t...
Next Document: Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of Fc?RIIB and dec...