| The impact of HIV drug resistance testing on changes to treatment. | |
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MedLine Citation:
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PMID: 21297420 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: We investigate changes made to therapy after a resistance test result and identify factors associated with switching regimen. METHODS:: Patients receiving antiretroviral therapy (ART) who had a resistance test performed during 1998-2007 were included in the analysis. A switch was defined as starting at least two drugs/starting a drug from a class not previously experienced within 4 months of the resistance test result. Logistic regression was used to identify factors independently associated with switching regimen. RESULTS:: Of the 5123 test results included in the analyses, 1874 (36.6%) were followed by a switch within 4 months of the test result. Independent factors associated with switching included genotypic sensitivity score (GSS) of the current regimen [odds ratio (OR) 4.86, 95% confidence interval (CI) 3.95, 5.97 for GSS less than 1 compared to GSS of at least 3] and a higher number of previous failures [1.12 (1.06, 1.18) per additional failed regimen]. Patients with fewer drug options were less likely to switch [0.36 (0.27, 0.48) comparing 0-3 drug options with ≥10 drug options]. CONCLUSIONS:: Only 37% of patients switched regimen within 4 months of the resistance test result. Whilst toxicity concerns of available drugs may somewhat explain this finding, it is also likely that there is a lack of treatment options available for patients who did not switch. |
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Authors:
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Loveleen Bansi; Colette Smith; Andrew Phillips; Stuart Kirk; Anna-Maria Geretti; Margaret Johnson; Nicola Mackie; Frank Post; Brian Gazzard; David Dunn; Caroline Sabin; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-3 |
Journal Detail:
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Title: AIDS (London, England) Volume: - ISSN: 1473-5571 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aResearch Department of Infection and Population Health, UCL Medical School, UK bUniversity College London Hospitals, UK cRoyal Free Hampstead NHS Trust & UCL Medical School, UK dImperial College Healthcare National Health Service Trust, UK eKing's College London School of Medicine, UK fChelsea and Westminster Hospital, UK gMRC Clinical Trials Unit, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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