| The immunosuppressive effects of Agyrolobium roseum and pinitol in experimental animals. | |
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MedLine Citation:
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PMID: 21156221 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Argyrolobium roseum (Papilionaceae) is a sexually reproducing, rare, annual herb that grows in tropical and sub-temperate tracts of the north-western Himalayan region of the Indian subcontinent. The present investigation was carried out to study the immunomodulatory properties of this herb in well established experimental models. For preliminary pharmacological activity evaluation, we first studied the effect of aqueous fraction (KA-134) of A. roseum on humoral and cell mediated immune responses and found that KA-134 dose dependently suppressed the antibody titre and delayed type hypersensitivity reaction. Inspired by the results, we further fractionated KA-134 which yielded pinitol, which on further immunomodulatory studies resulted in highly significant inhibition of CD3, CD19, CD4 and CD8 count and Th1/Th2 cytokines expression in splenocytes. Pinitol was also found to be safe when tested against cell viability assays (in vitro and in vivo). Based on the data, it can be suggested that pinitol is a potent and non-toxic immunosuppressor, which can be further explored for the development of potent immunosuppressor. |
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Authors:
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Prashant Singh Chauhan; Kuldeep Kumar Gupta; Sarang Bani |
Publication Detail:
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Type: Journal Article Date: 2010-12-13 |
Journal Detail:
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Title: International immunopharmacology Volume: 11 ISSN: 1878-1705 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 286-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Cell Biology Laboratory, Department of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi 180001, Jammu & Kashmir, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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