Document Detail

The immunosuppressive cytokines influence the fetal survival in patients with pregnancy-induced hypertension.
MedLine Citation:
PMID:  11076093     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The present study examines the hypothesis that the elevated levels of transforming growth factor (TGF)-beta1 and interleukin (IL)-10 would be protective for the fetus survival during pregnancy-induced hypertension (PIH). Moreover, we evaluate the IL-12 and IL-15 serum concentrations and their relationships with PIH. METHOD OF STUDY: Serum samples were obtained before the onset of labor from control and PIH groups. Cytokine concentrations were determined by Enzyme-Linked Immunoadsorbent Assay. RESULTS: Our data show that PIH women have significantly higher TGF-beta1 and IL-10 concentrations with respect to control groups (P = 0.0001). Similarly, macrophages from the PIH placentas produce in vitro more elevated TGF-beta1 and IL-10 levels compared to normal pregnant ones (P = 0.02), also in the absence of LPS stimulation. IL-12 and IL-15 serum concentrations were not detectable in all pregnant groups. CONCLUSION: We have found that PIH women have elevated concentrations of anti-inflammatory/immunosuppressive cytokines, suggesting their important role in fetal allograft protection during the normal and pathological pregnancy.
V Del Gobbo; M G Giganti; R Zenobi; V Villani; M G Premrov
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  44     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
Department of Experimental Medicine and Biochemical Sciences, School of Medicine, University of Rome Tor Vergata, Italy.
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MeSH Terms
Case-Control Studies
Cytokines / biosynthesis,  blood*
Decidua / immunology
Hypertension / immunology*
Interleukin-10 / biosynthesis,  blood
Interleukin-12 / biosynthesis,  blood
Interleukin-15 / biosynthesis,  blood
Macrophages / immunology
Pregnancy Complications, Cardiovascular / immunology*
Suppressor Factors, Immunologic / blood
Transforming Growth Factor beta / biosynthesis,  blood
Reg. No./Substance:
0/Cytokines; 0/Interleukin-15; 0/Suppressor Factors, Immunologic; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12

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