| An immunoserological study of patients with vibration syndrome. | |
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MedLine Citation:
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PMID: 1587628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a study undertaken to investigate the relationship between vibration syndrome and collagen disease, 90 Japanese patients with vibration syndrome (all men aged 41-86 years) were examined immunologic abnormalities, mainly by a set of immunoserology tests. Of these 90 patients, 25 had examinations at yearly intervals for 3 consecutive years, while the other 65 underwent examinations once. The results indicate that, of all the patients studied, 10 (11.1%) gave a positive RA test, 6 (6.7%) had leukopenia, 5 (5.6%) had hypergammaglobulinemia, and 15 (16.7%) had hypocomplementemia (CH50). Worthy of particular note are the 21 patients (23.3%) who were positive for nuclear-specific antibodies (1: greater than or equal to 40) (using Hep-2 cells as the nuclear substrate), with some of them suspected of having Sjögren's syndrome, progressive systemic sclerosis, or systemic lupus erythematosus. During a 3-year follow-up period, 10 (40%) of 25 patients exhibited rising titers of nuclear-specific antibodies with conversion to seropositivity for these antibodies. The facts that the positivity rate for nuclear-specific antibodies was significantly higher in these patients with vibration syndrome (23.3%) than in healthy adult men over 40 years of age (1.8%) (P less than 0.05) and that a progressive elevation of nuclear-specific antibody titer was noted in a high percentage of the patients were suggestive of some causal relationship between the appearance of nuclear-specific antibodies and the use of vibrating tools. |
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Authors:
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Y Matsumoto; T Yasue; H Miyagawa; N Mizuno; I Yoshida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International archives of occupational and environmental health Volume: 63 ISSN: 0340-0131 ISO Abbreviation: Int Arch Occup Environ Health Publication Date: 1992 |
Date Detail:
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Created Date: 1992-06-25 Completed Date: 1992-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7512134 Medline TA: Int Arch Occup Environ Health Country: GERMANY |
Other Details:
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Languages: eng Pagination: 537-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Nagoya University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Antinuclear / analysis* Collagen Diseases / etiology*, immunology Humans Male Middle Aged Occupational Exposure / adverse effects* Retrospective Studies Vibration / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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