| The immunopathophysiology of multiple sclerosis. | |
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MedLine Citation:
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PMID: 21439440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons. This article preferentially focuses on MS rather than animal models of the disease, such as experimental autoimmune encephalomyelitis. |
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Authors:
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Gregory F Wu; Enrique Alvarez |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurologic clinics Volume: 29 ISSN: 1557-9875 ISO Abbreviation: Neurol Clin Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-07-19 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: United States |
Other Details:
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Languages: eng Pagination: 257-78 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Multiple Sclerosis, Department of Neurology, Washington University, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA. wug@neuro.wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / pathology Axons / pathology Brain / pathology Cytokines / metabolism Humans Leukocytes / physiology Lymphocytes / physiology Models, Biological Multiple Sclerosis / immunology*, metabolism, pathology* Neurons / pathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS062138-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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