Document Detail


The immunology of susceptibility and resistance to Leishmania major in mice.
MedLine Citation:
PMID:  12415308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania major -- involving the early production of interleukin-4 by a small subset of Leishmania-specific CD4+ T cells -- have been refined by accumulating evidence that this response is not sufficient and, under some circumstances, not required to promote susceptibility. In addition, more recent studies in L. major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses.
Authors:
David Sacks; Nancy Noben-Trauth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  2     ISSN:  1474-1733     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2002-12-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  845-58     Citation Subset:  IM    
Affiliation:
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. dsacks@nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / immunology
Disease Susceptibility / immunology
Humans
Interleukin-12 / physiology
Interleukin-4 / physiology
Leishmania major / immunology*
Leishmaniasis, Cutaneous / immunology*
Mice
Mice, Inbred BALB C
Protozoan Vaccines / immunology
Th1 Cells / immunology
Th2 Cells / immunology
Chemical
Reg. No./Substance:
0/Protozoan Vaccines; 187348-17-0/Interleukin-12; 207137-56-2/Interleukin-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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