Document Detail

An immunologist's guide to CD31 function in T-cells.
MedLine Citation:
PMID:  23761922     Owner:  NLM     Status:  MEDLINE    
Although it is expressed by all leukocytes, including T-, B-lymphocytes and dendritic cells, the immunoglobulin-like receptor CD31 is generally regarded by immunologists as a marker of endothelial cell lineage that lacks an established functional role in adaptive immunity. This perception has recently been challenged by studies that reveal a key role for this molecule in the regulation of T-cell homeostasis, effector function and trafficking. The complexity of the biological functions of CD31 results from the integration of its adhesive and signaling functions in both the immune and vascular systems. Signaling by means of CD31 is induced by homophilic engagement during the interactions of immune cells and is mediated by phosphatase recruitment or activation through immunoreceptor tyrosine inhibitory motifs (ITIMs) that are located in its cytoplasmic tail. Loss of CD31 function is associated with excessive immunoreactivity and susceptibility to cytotoxic killing. Here, we discuss recent findings that have brought to light a non-redundant, complex role for this molecule in the regulation of T-cell-mediated immune responses, with large impact on our understanding of immunity in health and disease.
Federica M Marelli-Berg; Marc Clement; Claudio Mauro; Giuseppina Caligiuri
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  126     ISSN:  1477-9137     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-11-12     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2343-52     Citation Subset:  IM    
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MeSH Terms
Antigens, CD31 / genetics,  immunology*
Cell Adhesion / genetics,  immunology
Cell Movement / genetics,  immunology*
Immunity, Cellular*
Signal Transduction / genetics,  immunology*
T-Lymphocytes / immunology*
Grant Support
FS/11/64/2894//British Heart Foundation; FS/12/38/29640//British Heart Foundation; PG/05/136/19997//British Heart Foundation; RG/09/002/26425//British Heart Foundation
Reg. No./Substance:
0/Antigens, CD31

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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