| The immunolocalization of ACTH and alpha MSH in human and rat pituitaries. | |
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MedLine Citation:
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PMID: 188228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human and rat pituitaries were investigated immunohistochemically for ACTH and alpha MSH activity by means of the enzyme-labeling technique. In rat pituitaries cells present in both the anterior and intermediate lobes were reactive with the anti-ACTH antibodies, the cells from the intermediate lobe were also reactive with anti-alpha MSH antibodies. In human pituitaries, ACTH-immunoreactivity was found in cells from the anterior lobe and cells invading the posterior lobe. In 5 out of 15 pituitaries ACTH-immunoreactive cells located at or invading the posterior lobe were also reactive with the anti-alpha MSH antibodies. It is concluded that the human pituitary cells that invade the posterior lobe represent a population which is at least immunohistochemically identical with the intermediate lobe cells of the rat. The ACTH-immunoreactivity of intermediate lobe cells may be explained by the presence of a corticotropin-like intermediate lobe peptide (CLIP) which has been suggested to be a prohormonal fragment of alpha MSH. |
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Authors:
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A C Nieuwenhuijzen Kruseman; J P Schröder-van der Elst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virchows Archiv. B: Cell pathology Volume: 22 ISSN: 0340-6075 ISO Abbreviation: Virchows Arch B Cell Pathol Publication Date: 1976 Dec |
Date Detail:
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Created Date: 1977-02-16 Completed Date: 1977-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0437105 Medline TA: Virchows Arch B Cell Pathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 263-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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analysis* Animals Female Humans Immunoenzyme Techniques Male Melanocyte-Stimulating Hormones / analysis* Pituitary Gland / analysis* Pituitary Gland, Anterior / analysis Pituitary Gland, Posterior / analysis Rats |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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