Document Detail

The immunolocalization of ACTH and alpha MSH in human and rat pituitaries.
MedLine Citation:
PMID:  188228     Owner:  NLM     Status:  MEDLINE    
Human and rat pituitaries were investigated immunohistochemically for ACTH and alpha MSH activity by means of the enzyme-labeling technique. In rat pituitaries cells present in both the anterior and intermediate lobes were reactive with the anti-ACTH antibodies, the cells from the intermediate lobe were also reactive with anti-alpha MSH antibodies. In human pituitaries, ACTH-immunoreactivity was found in cells from the anterior lobe and cells invading the posterior lobe. In 5 out of 15 pituitaries ACTH-immunoreactive cells located at or invading the posterior lobe were also reactive with the anti-alpha MSH antibodies. It is concluded that the human pituitary cells that invade the posterior lobe represent a population which is at least immunohistochemically identical with the intermediate lobe cells of the rat. The ACTH-immunoreactivity of intermediate lobe cells may be explained by the presence of a corticotropin-like intermediate lobe peptide (CLIP) which has been suggested to be a prohormonal fragment of alpha MSH.
A C Nieuwenhuijzen Kruseman; J P Schröder-van der Elst
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. B: Cell pathology     Volume:  22     ISSN:  -     ISO Abbreviation:  Virchows Arch B Cell Pathol     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  0437105     Medline TA:  Virchows Arch B Cell Pathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  263-72     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / analysis*
Immunoenzyme Techniques
Melanocyte-Stimulating Hormones / analysis*
Pituitary Gland / analysis*
Pituitary Gland, Anterior / analysis
Pituitary Gland, Posterior / analysis
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones

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