Document Detail

The immunoinformatics of cancer immunotherapy.
MedLine Citation:
PMID:  17767547     Owner:  NLM     Status:  MEDLINE    
We review here the developments in the field of immunoinformatics and their present and potential applications to the immunotherapeutic treatment of cancer. Antigen presentation plays a central role in the immune response, and as a result in immunotherapeutic methods such as adoptive T-cell transfer and antitumor vaccination. We therefore extensively review the current technologies of antigen presentation prediction, including the next generation predictors, which combine proteasomal processing, transporter associated with antigen processing and major histocompatibility complex (MHC)-binding prediction. Minor histocompatibility antigens are also relevant targets for immunotherapy, and we review the current systems available, SNEP and SiPep. Here, antigen presentation plays a key role, but additional types of data are also incorporated, such as single nucleotide polymorphism data and tissue/cell-type expression data. Current systems are not capable of handling the concept of immunodominance, which is critical to immunotherapy, but efforts have been made to model general aspects of the immune system. Although tough challenges lie ahead, when measuring the field of immunoinformatics on its contributions thus far, one can expect fruitful developments in the future.
D S Deluca; R Blasczyk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Tissue antigens     Volume:  70     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-04     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Institute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Street 1, 30625 Hannover, Germany.
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MeSH Terms
ATP-Binding Cassette Transporters / immunology,  metabolism
Antigen Presentation*
Antigens, Neoplasm
Cancer Vaccines / immunology*
Graft vs Host Disease
Histocompatibility Antigens Class I / immunology*,  metabolism
Histocompatibility Antigens Class II / immunology*,  metabolism
Models, Immunological
Neoplasms / immunology,  therapy*
Proteasome Endopeptidase Complex / immunology,  metabolism
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Antigens, Neoplasm; 0/Cancer Vaccines; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; EC Endopeptidase Complex

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