Document Detail

An immunohistochemical study of thymic epithelial tumors. I. Epithelial component.
MedLine Citation:
PMID:  2420219     Owner:  NLM     Status:  MEDLINE    
Twenty-four cases of thymic epithelial tumors, including 18 cases of thymoma, five cases of squamous cell carcinoma, and one case of undifferentiated carcinoma, were studied immunohistochemically using monoclonal antibody Leu-7 (HNK-1) and antikeratin antibody. Seven cases of non-neoplastic thymic tissues were also studied. Leu-7 antibody stained epithelial cells in the outer cortex of the normal thymus, and antikeratin antibody stained thymic epithelial cells in both cortex and medulla of the normal thymus. Seventeen thymomas and one undifferentiated carcinoma were focally or diffusely stained with Leu-7, some showing cortical and medullary differentiation as seen in the normal thymus. On the other hand, none of the five squamous cell carcinomas were stained with Leu-7. All thymomas stained for keratin in varying degrees, and all squamous cell carcinomas were diffusely and strongly stained with antikeratin antibody. It is concluded that normal thymic epithelial cells showed zonal differentiation, and neoplastic cells were considered to retain these characteristics to some extent; i.e., thymomas had the same phenotype of epithelial cells of the cortex, especially the outer cortex of the thymus in some instances (Leu-7-positive, keratin-positive) and of both cortex and medulla (mixture of Leu-7-positive and -negative cells) with organoid arrangement in other instances, and thymic squamous cell carcinoma had the same phenotype as epithelial cells in the thymic medulla (Leu-7-negative, keratin-positive).
T Kodama; S Watanabe; Y Sato; Y Shimosato; N Miyazawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  10     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-01     Completed Date:  1986-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-33     Citation Subset:  IM    
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MeSH Terms
Antigens, Surface / analysis
Carcinoma / immunology,  pathology*
Carcinoma, Squamous Cell / immunology,  pathology*
Epithelium / pathology
Immunoenzyme Techniques
Keratins / metabolism
Thymoma / immunology,  pathology*
Thymus Neoplasms / immunology,  pathology*
Reg. No./Substance:
0/Antigens, Surface; 68238-35-7/Keratins

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