| An immunohistochemical study of pheochromocytomas. | |
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MedLine Citation:
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PMID: 6203498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty -six adrenal pheochromocytomas and four normal adrenal medullae were studied immunohistochemically. These included four malignant tumors with proven metastases, six tumors in patients with neurofibromatosis, nine tumors in patients with multiple endocrine neoplasia type 2, and seven sporadic nonfamilial pheochromocytomas. Immunohistochemical localization of neuron-specific enolase (NSE) was seen in all tumors and in the four normal adrenals. Methionine enkephalin-like immunoreactivity was present in tumors from all four groups and in the normal adrenals. Corticotropinlike immunoreactivity was found focally in two normal adrenal medullae and in four benign pheochromocytomas. Our results indicated that NSE was present in all four major groups of pheochromocytomas, including benign and malignant tumors. This marker aided in distinguishing between adrenal cortical and medullary tumors in unusually difficult cases, since all normal adrenal cortex and adrenal cortical tumors had negative test results for NSE. |
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Authors:
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R V Lloyd; B Shapiro; J C Sisson; V Kalff; N W Thompson; W A Beierwaltes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 108 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-07-18 Completed Date: 1984-07-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 541-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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14-3-3 Proteins Adrenal Gland Neoplasms / pathology* Adrenocorticotropic Hormone / immunology Enkephalins / immunology Evaluation Studies as Topic Histocytochemistry* Humans Immunochemistry* Nerve Tissue Proteins / analysis Neurofibroma / pathology Pheochromocytoma / pathology* Staining and Labeling Tyrosine 3-Monooxygenase* |
| Chemical | |
Reg. No./Substance:
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0/14-3-3 Proteins; 0/Enkephalins; 0/Nerve Tissue Proteins; 9002-60-2/Adrenocorticotropic Hormone; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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