Document Detail

An immunohistochemical study of osteopontin in pigment gallstone formation.
MedLine Citation:
PMID:  20135947     Owner:  NLM     Status:  MEDLINE    
Mucin glycoproteins from the gallbladder epithelium are thought to contribute to the matrix or nucleus of gallstones and other biomineralization systems. The involved acidic glycoproteins have been reported in bile and gallstones. In addition, osteopontin (Opn) is a noncollagenous acidic bone matrix glycoprotein that possesses calcium-binding properties. To investigate the role of Opn in pigment gallstone formation, the involvement of Opn in pigment gallstone formation was studied immunohistochemically in the gallbladder wall and in the stones. Staining for Opn was strongly positive in the epithelium of stone-laden gallbladders and in their stones. The stone-laden gallbladders were infiltrated by macrophages, which intensely stained for Opn. Sections of the pigment stones, under low magnification, showed a lamellar pattern of Opn immunolabeling and showed a reticular pattern under high magnification. Our results indicate that Opn, an acidic glycoprotein from the gallbladder epithelium, seems to be involved in lithiasis. Opn from macrophages and/or the epithelium seems to help form the matrix protein.
Motohiro Imano; Takao Satou; Tatsuki Itoh; Yoshifumi Takeyama; Atsushi Yasuda; Ying-Feng Peng; Masayuki Shinkai; Seiji Haji; Chikao Yasuda; Takuya Nakai; Takushi Yasuda; Haruhiko Imamoto; Kiyotaka Okuno; Hitoshi Shiozaki; Harumasa Ohyanagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  76     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
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MeSH Terms
Case-Control Studies
Cholecystolithiasis / immunology,  metabolism,  physiopathology*
Gallbladder / immunology,  metabolism,  physiopathology*
Gallstones / immunology,  metabolism,  physiopathology*
Macrophages / metabolism
Middle Aged
Osteopontin / immunology,  metabolism*
Reg. No./Substance:
106441-73-0/Osteopontin; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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