Document Detail


An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: Normal breast and benign proliferative lesions.
MedLine Citation:
PMID:  1384226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of simple epithelial (K8/18/19) and basal (myoepithelial) (K5/14) keratins, alpha-smooth-muscle actin, vimentin, collagen IV and laminin in normal mammary glands and in benign proliferative lesions was studied using monoclonal antibodies (mAbs). These antibodies (Abs) identified myoepithelial cells and luminal cells specifically. In lesions with adenosis and papillomas, the two-layered formation resembled that of normal glands with a purely myoepithelial-epithelial differentiation. In scleradenotic lesions, the main cell was of myoepithelial immunophenotype with intermixed trabecular-tubular proliferations of simple-type epithelium. The sclerosis seems to be the result of an irregular basal lamina synthesis by the myoepithelial cells. In contrast to these lesions, epitheliosis represents a purely intraluminal cell proliferation of clearly simple epithelial immunophenotype and of cells with a basal keratin phenotype, lacking myoepithelial differentiation antigen actin. The basal keratin type epithelium may represent post-stem or intermediate cells developing into luminal epithelium. Epitheliosis appears to be a purely epithelial hyperplasia with striking similarity to the regeneration of normal breast epithelium. The different proliferative patterns may give an explanation for differences in potential cancer risks of patients with these lesions.
Authors:
W Böcker; B Bier; G Freytag; B Brömmelkamp; E D Jarasch; G Edel; B Dockhorn-Dworniczak; K W Schmid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  421     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Affiliation:
Gerhard Domagk Institute of Pathology, University of Münster, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Actins / immunology
Adenoma / chemistry,  pathology
Antibodies, Monoclonal / analysis*
Breast / chemistry,  pathology*
Breast Neoplasms / chemistry,  pathology*
Cell Division
Collagen / analysis
Epithelium / chemistry,  pathology
Female
Humans
Keratins / immunology
Laminin / analysis
Muscles / chemistry
Papilloma / chemistry,  pathology
Tumor Markers, Biological / analysis*
Vimentin / immunology
Chemical
Reg. No./Substance:
0/Actins; 0/Antibodies, Monoclonal; 0/Laminin; 0/Tumor Markers, Biological; 0/Vimentin; 68238-35-7/Keratins; 9007-34-5/Collagen

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