Document Detail

An immunohistochemical study of CD1a and CD83-positive infiltrating dendritic cell density in cervical neoplasia.
MedLine Citation:
PMID:  17197902     Owner:  NLM     Status:  MEDLINE    
Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86. By identifying CD1a and CD83, theoretically, both immature and mature dentritic cell populations can be studied. In view of the facts, we investigated the infiltrating cell density of mature and immature dentritic cells in cervical neoplasia.
Abdul Rahman Hayati; Mohammad Zulkarnaen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  26     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
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MeSH Terms
Antigens, CD / immunology,  metabolism*
Antigens, CD1 / immunology,  metabolism*
Cell Count
Cell Differentiation
Dendritic Cells / cytology*,  immunology
Immunoglobulins / immunology,  metabolism*
Membrane Glycoproteins / immunology,  metabolism*
Uterine Cervical Neoplasms / immunology*,  metabolism*,  pathology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD1; 0/CD1a antigen; 0/CD83 antigen; 0/Immunoglobulins; 0/Membrane Glycoproteins

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