| The immunohistochemical characteristics of the basosquamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 9145960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The basosquamous cell carcinoma (BSCC) is a poorly defined and often misunderstood cutaneous malignancy. OBJECTIVE: The purpose of this study was to compare, using immunohistochemical techniques, the BSCC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). METHODS: BSCC occurring at Pennsylvania State University over the past 10 years were identified. Choosing seven BCC, and nine SCC as controls, all specimens were stained for keratin, lack of apoptosis, glycoproteins, and altered gene products using the avidin/biotin and strep-avidin immunoperoxidase techniques. Each malignancy was then graded for the percentage of cells stained with each marker. RESULTS: Of the markers studied, all stained to varying degrees the malignant aspects of the specimens. There were similar patterns between tumors, with the BSCC showing a transition zone between typical BCC and SCC. This was most striking for Ber-EP4, where over two-thirds of the BCC stained, none of the SCC, and half of the BSCC showed reactivity. CONCLUSION: BSCC has staining patterns similar to both the BCC and SCC. The presence of a transition zone does not support the concept that all BSCC are collision tumors, but rather a differentiation of one tumor into another. We confirm earlier reports that Ber-EP4 could be used to distinguish between classic BCC and SCC. AE1/AE3, bcl-2, TGF-alpha, and p53 were not helpful in separating the tumors. |
| | |
Authors:
|
M S Jones; K F Helm; M E Maloney |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 23 ISSN: 1076-0512 ISO Abbreviation: Dermatol Surg Publication Date: 1997 Mar |
Date Detail:
|
Created Date: 1997-06-02 Completed Date: 1997-06-02 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
|
Division of Dermatology, Pennsylvania State University, Hershey, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Basal Cell
/
chemistry,
diagnosis Carcinoma, Basosquamous / chemistry*, diagnosis Carcinoma, Squamous Cell / chemistry, diagnosis Diagnosis, Differential Humans Immunohistochemistry Keratins / analysis Membrane Glycoproteins / analysis Proto-Oncogene Proteins c-bcl-2 / analysis Receptor, Epidermal Growth Factor / analysis Skin Neoplasms / chemistry*, diagnosis Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Membrane Glycoproteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53; 68238-35-7/Keratins; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glycolic acid peels in the treatment of melasma among Asian women.
Next Document: Saturated phenol as a local anesthetic for manual dermabrasion.