| The immunoglobulin-bearing cells in the lamina propria and the clinical response to a gluten-free diet in dermatitis herpetiformis. | |
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MedLine Citation:
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PMID: 329776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 17 patients with DH, multiple duodenal and jejunal biopsies were performed. In all patients the small-intestinal biopsy-specimens showed histopathological changes compatible with coeliac disease. Fourteen of the patients maintained a gluten-free diet (GFD) for more than 8 months. The small-intestinal lesions improved in all patients investigated during the GFD. The dosage of Dapsone needed to control the sin lesions could be reduced by more than 50% in 4 patients and the Dapsone could be stopped in 5 other patients on GFD. The immunoglobulin-bearing cells in the lamina propria were counted in 8 patients not on a gluten-free diet, in 6 patients on gluten-free diet, and in 8 healthy controls. The numbers of IgA-, IgM- and IgG-bearing cells were increased in most of the DH patients who were not on a gluten-free diet. The number of IgM-bearing cells in the DH patients who were on a gluten-free diet was the same as that in the control group. This may indicate a mainly IgM response in the lamina propria induced by gluten. |
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Authors:
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B J Vermeer; J Lindeman; C J van der Harst-Oostveen; A S Peña; W A van Vloten |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives for dermatological research. Archiv für dermatologische Forschung Volume: 258 ISSN: 0340-3696 ISO Abbreviation: Arch Dermatol Res Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-09-17 Completed Date: 1977-09-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7512589 Medline TA: Arch Dermatol Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 223-30 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cell Count Dapsone / administration & dosage* Dermatitis Herpetiformis / diet therapy, drug therapy, immunology*, pathology Female Fluorescent Antibody Technique Follow-Up Studies Glutens* Humans Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins* Intestinal Mucosa / immunology*, pathology Jejunum / immunology*, pathology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 80-08-0/Dapsone; 8002-80-0/Glutens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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