Document Detail

The immunoglobulin-bearing cells in the lamina propria and the clinical response to a gluten-free diet in dermatitis herpetiformis.
MedLine Citation:
PMID:  329776     Owner:  NLM     Status:  MEDLINE    
In 17 patients with DH, multiple duodenal and jejunal biopsies were performed. In all patients the small-intestinal biopsy-specimens showed histopathological changes compatible with coeliac disease. Fourteen of the patients maintained a gluten-free diet (GFD) for more than 8 months. The small-intestinal lesions improved in all patients investigated during the GFD. The dosage of Dapsone needed to control the sin lesions could be reduced by more than 50% in 4 patients and the Dapsone could be stopped in 5 other patients on GFD. The immunoglobulin-bearing cells in the lamina propria were counted in 8 patients not on a gluten-free diet, in 6 patients on gluten-free diet, and in 8 healthy controls. The numbers of IgA-, IgM- and IgG-bearing cells were increased in most of the DH patients who were not on a gluten-free diet. The number of IgM-bearing cells in the DH patients who were on a gluten-free diet was the same as that in the control group. This may indicate a mainly IgM response in the lamina propria induced by gluten.
B J Vermeer; J Lindeman; C J van der Harst-Oostveen; A S Peña; W A van Vloten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives for dermatological research. Archiv für dermatologische Forschung     Volume:  258     ISSN:  -     ISO Abbreviation:  Arch Dermatol Res     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  7512589     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
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MeSH Terms
Cell Count
Dapsone / administration & dosage*
Dermatitis Herpetiformis / diet therapy,  drug therapy,  immunology*,  pathology
Fluorescent Antibody Technique
Follow-Up Studies
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Intestinal Mucosa / immunology*,  pathology
Jejunum / immunology*,  pathology
Middle Aged
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 8002-80-0/Glutens; 8W5C518302/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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