Document Detail

The immunogenicity of Haemophilus influenzae type b conjugate (HbOC) vaccine in human immunodeficiency virus-infected and uninfected infants.
MedLine Citation:
PMID:  7638008     Owner:  NLM     Status:  MEDLINE    
Enzyme-linked immunosorbent assay polyribosyl ribitol phosphate (PRP) antibody responses to Haemophilus influenzae type b conjugate vaccine (HbOC) given at 2, 4 and 6 months of age were retrospectively compared in 23 human immunodeficiency virus (HIV) and 24 non-HIV-infected infants. HIV-infected infants were divided into those who were P1 (asymptomatic) or P2 (symptomatic) by 1 year of age. The P2 group was further divided into P2A (mildly symptomatic) and > P2A (rapidly symptomatic) by 1 year of age. The post-third HbOC dose geometric mean antibody titer to PRP was significantly lower in 12 P2 infants (0.43 microgram/ml) than either the 11 P1 infants (5.03 micrograms/ml, P < 0.05) or the 24 non-HIV infected infants (3.43 micrograms/ml, P < 0.05). Within the P2 group, the geometric mean antibody titer to PRP was significantly higher in 5 P2A infants (1.63 micrograms/ml) compared with 7 infants who were > P2A (0.17 microgram/ml, P < 0.05). After the third HbOC dose, PRP antibody titers were > or = 1.0 micrograms/ml for 4 of 12 P2 compared with 9 of 11 P1 infants (P < 0.05). Within the P2 group, PRP antibody titers were > 1.0 micrograms/ml for 4 of 5 P2A compared to 0 of 7 infants who were > P2A (P < 0.05). HIV-infected infants with PRP antibody titers > or = 1.0 micrograms/ml after the third HbOC dose had significantly higher mean CD4 counts (2842 cells/mm3) at the time of the third HbOC dose than those with lower PRP titers (1655 cells/mm3) (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
K L Kale; J C King; J J Farley; P E Vink; C O Cimino; P R Paradiso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  14     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-11     Completed Date:  1995-09-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-4     Citation Subset:  IM; X    
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Antibodies, Bacterial / biosynthesis*
Bacterial Proteins / administration & dosage,  immunology*
HIV Infections / immunology*,  physiopathology
Haemophilus Infections / immunology,  prevention & control*
Haemophilus Vaccines / administration & dosage,  immunology*
Haemophilus influenzae / immunology*
Immunoglobulin G / biosynthesis*
Infant, Newborn
Polysaccharides / biosynthesis*
Retrospective Studies
Grant Support
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Haemophilus Vaccines; 0/Immunoglobulin G; 0/Polysaccharides; 126161-67-9/HibTITER protein, Haemophilus influenzae; 51584-96-4/polyribitol phosphate

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