| The immunogenicity of Haemophilus influenzae type b conjugate (HbOC) vaccine in human immunodeficiency virus-infected and uninfected infants. | |
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MedLine Citation:
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PMID: 7638008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enzyme-linked immunosorbent assay polyribosyl ribitol phosphate (PRP) antibody responses to Haemophilus influenzae type b conjugate vaccine (HbOC) given at 2, 4 and 6 months of age were retrospectively compared in 23 human immunodeficiency virus (HIV) and 24 non-HIV-infected infants. HIV-infected infants were divided into those who were P1 (asymptomatic) or P2 (symptomatic) by 1 year of age. The P2 group was further divided into P2A (mildly symptomatic) and > P2A (rapidly symptomatic) by 1 year of age. The post-third HbOC dose geometric mean antibody titer to PRP was significantly lower in 12 P2 infants (0.43 microgram/ml) than either the 11 P1 infants (5.03 micrograms/ml, P < 0.05) or the 24 non-HIV infected infants (3.43 micrograms/ml, P < 0.05). Within the P2 group, the geometric mean antibody titer to PRP was significantly higher in 5 P2A infants (1.63 micrograms/ml) compared with 7 infants who were > P2A (0.17 microgram/ml, P < 0.05). After the third HbOC dose, PRP antibody titers were > or = 1.0 micrograms/ml for 4 of 12 P2 compared with 9 of 11 P1 infants (P < 0.05). Within the P2 group, PRP antibody titers were > 1.0 micrograms/ml for 4 of 5 P2A compared to 0 of 7 infants who were > P2A (P < 0.05). HIV-infected infants with PRP antibody titers > or = 1.0 micrograms/ml after the third HbOC dose had significantly higher mean CD4 counts (2842 cells/mm3) at the time of the third HbOC dose than those with lower PRP titers (1655 cells/mm3) (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K L Kale; J C King; J J Farley; P E Vink; C O Cimino; P R Paradiso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 14 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-09-11 Completed Date: 1995-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: IM; X |
Affiliation:
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Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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biosynthesis* Bacterial Proteins / administration & dosage, immunology* Female HIV Infections / immunology*, physiopathology Haemophilus Infections / immunology, prevention & control* Haemophilus Vaccines / administration & dosage, immunology* Haemophilus influenzae / immunology* Humans Immunoglobulin G / biosynthesis* Infant Infant, Newborn Male Polysaccharides / biosynthesis* Prognosis Retrospective Studies Vaccination |
| Grant Support | |
ID/Acronym/Agency:
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DA 04312/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Haemophilus Vaccines; 0/Immunoglobulin G; 0/Polysaccharides; 126161-67-9/HibTITER protein, Haemophilus influenzae; 51584-96-4/polyribitol phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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