Document Detail

An immunocytochemical study of the inflammatory cell infiltrate and epithelial expression of HLA-DR in odontogenic cysts.
MedLine Citation:
PMID:  3114449     Owner:  NLM     Status:  MEDLINE    
The presence and distribution of lymphocytes, Langerhans cells, HLA-DR+ infiltrating cells and the expression of HLA-DR by lining epithelium was investigated in the walls of odontogenic cysts using an indirect immunoperoxidase method on acetone-fixed cryostat sections. The 23 cysts studied consisted of 14 dental (radicular) cysts, 5 keratocysts, 2 dentigerous cysts, 1 surgical ciliated cyst and 1 incisive canal cyst. The cell populations detected in the walls of all cysts were similar and consisted of HLA-DR+ macrophage-type cells and a mixture of T and B lymphocytes. Analysis of the T cell subsets revealed that in all cases the CD4+, Th/i subset predominated over the CD8+, Ts/c subset. 18/22 cyst linings contained cells expressing a Langerhans cell phenotype (CD1+). Cytoplasmic epithelial expression of HLA-DR was detected in 7/22 specimens. Neither the presence of HLA-DR+ epithelial cells nor LC were restricted to a given type of cyst. These findings indicate the occurrence of similar cellular processes irrespective of the proposed developmental or inflammatory aetiology of these lesions.
J B Matthews; R M Browne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology     Volume:  16     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-10-07     Completed Date:  1987-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  D; IM    
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MeSH Terms
Cell Count
Epithelium / metabolism,  pathology
HLA-D Antigens / analysis*
HLA-DR Antigens / analysis*
Immunoenzyme Techniques
Jaw Diseases / metabolism,  pathology*
Langerhans Cells / metabolism,  pathology*
Lymphocytes / metabolism,  pathology*
Odontogenic Cysts / metabolism,  pathology*
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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