Document Detail

An immunoassay for anti-neuronal antibodies associated with involuntary repetitive movement disorders.
MedLine Citation:
PMID:  9142376     Owner:  NLM     Status:  MEDLINE    
Tourette's syndrome (TS) is a complex neurobehavioral disorder emerging in childhood and is characterized by motor and vocal tics of at least one year in duration. In a portion of patients with TS, environmental (non-genetic) factors may either have an etiologic role or act to modulate the phenotype. One possible environmental factor may be antibodies to central nervous system cells, as sera from several children diagnosed with either TS or Sydenham's chorea contained anti-neuronal antibodies. Using enriched membrane preparations isolated from HTB-10 neuroblastoma cells, a sensitive and specific assay was developed for the determination of human anti-neuronal antibodies associated with involuntary repetitive movement disorders. This assay exhibited between-run and within-run precision of 11.3 percent and 5.9 percent, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of this assay for the diagnosis of TS and TS or chorea are 79.1 percent, 61.2 percent, 61.6 percent, 78.8 percent, and 71.1 percent, 60.9 percent, 68.6 percent, and 63.6 percent, respectively. In addition, there was a significant difference (p < 0.0001) between the mean optical density in the patients with TS and children determined to be clinically "normal".
J P Laurino; J Hallett; L S Kiessling; M Benson; T Pelletier; C Kuhn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  27     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-5     Citation Subset:  IM    
Department of Pathology, Brown University, School of Medicine, Providence, RI 02919, USA.
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MeSH Terms
Autoantibodies / blood*
Cell Membrane / immunology
Enzyme-Linked Immunosorbent Assay / methods*
Neurons / immunology*
Sensitivity and Specificity
Tourette Syndrome / diagnosis,  immunology*
Tumor Cells, Cultured
Reg. No./Substance:

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