Document Detail


Passive/active immunization against hepatitis B.
MedLine Citation:
PMID:  6235294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No differences in eventual immune-response rates were found between 325 subjects immunized passively/actively against hepatitis B and a control group of 108 subjects vaccinated only actively. The geometric mean titers of antibodies to hepatitis B surface antigen were nearly identical in controls and in a group of 87 individuals immunized passively/actively with the same vaccine lot. Lower geometric mean titers of antibodies to hepatitis B surface antigen were seen in 238 individuals who were vaccinated passively/actively with a different vaccine lot, a difference that may be explained by a somewhat lower immunogenicity in this particular lot. The mean half-life of hepatitis B immunoglobulin was calculated as 24.8 days, and in approximately 90% of vaccines 300,000 mIU of hepatitis B immunoglobulin provided protection until an active immune response had developed.
Authors:
R Zachoval; W Jilg; B Lorbeer; M Schmidt; F Deinhardt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  150     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-27     Completed Date:  1984-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Female
Half-Life
Hepatitis B / immunology*
Hepatitis B Antibodies / biosynthesis*
Hepatitis B Surface Antigens / immunology
Hepatitis B Vaccines
Hepatitis B virus / immunology*
Humans
Immunization, Passive* / adverse effects
Male
Sex Factors
Time Factors
Vaccination* / adverse effects
Viral Vaccines / immunology*
Chemical
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines; 0/Viral Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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