Document Detail


The immunohistochemical examination of GABAergic interneuron markers in the dorsolateral prefrontal cortex of patients with late-life depression.
MedLine Citation:
PMID:  21044398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The "vascular depression" hypothesis has sought to explain differences in etiology between early and late life depression, and has been reinforced by recent imaging and morphometric studies. Gamma-aminobutyric acid (GABA) is thought to play a major role in the neurobiology of depression. However, it is unclear whether there is an effect on GABA neuronal subpopulations in an elderly depressed cohort. This study therefore examined immunohistochemically two calcium-binding proteins, calretinin and parvalbumin, which have been demonstrated to bind to two distinct GABAergic interneuron subpopulations, within the dorsolateral prefrontal cortex (DLPFC) of elderly depressed patients, against age-matched controls.
METHODS: Post-mortem tissue was obtained from nine controls and 11 depressed patients for the parvalbumin study and seven controls and 14 depressed patients in the calretinin study, and the mean percentage per area of immunohistochemical staining of the two antibodies was measured in individual layers and across the whole of the DLPFC.
RESULTS: The study found a reduction in parvalbumin immunostaining in layer 6 (p = 0.05) of the DLFPC in elderly depressed patients. However, no significant changes were found in parvalbumin or calretinin immunostaining in the any other layer of the DLPFC in elderly depressed patients.
CONCLUSION: The study does not suggest any change in GABA interneuron subpopulations, though significant reductions in layer 6 may represent subtle disturbance in GABA parvalbumin-expressing interneuron and glumatatergic pyramidal projection neuron regulation in late-life depression.
Authors:
Ahmad Khundakar; Christopher Morris; Alan J Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-03
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  23     ISSN:  1741-203X     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-24     Completed Date:  2011-08-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  644-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / metabolism*
Biological Markers
Calbindin 2
Case-Control Studies
Depression / metabolism*
Female
Humans
Immunohistochemistry
Interneurons / metabolism*
Male
Parvalbumins / metabolism
Postmortem Changes
Prefrontal Cortex / metabolism*
S100 Calcium Binding Protein G / metabolism
gamma-Aminobutyric Acid / metabolism*
Grant Support
ID/Acronym/Agency:
G0400074//Medical Research Council; G0502157//Medical Research Council; G0900652//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CALB2 protein, human; 0/Calbindin 2; 0/Parvalbumins; 0/S100 Calcium Binding Protein G; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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