Document Detail


The immune system and hypertension.
MedLine Citation:
PMID:  1730453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary or secondary activation of immune mechanisms has been implicated in the pathogenesis of many forms of hypertension. Changes in serum immunoglobulin levels, alterations in both humoral and cellular immune functions, and inherited abnormalities of the complement system have been identified in patients with essential hypertension. In addition, many models of spontaneous hypertension (such as the Okamoto and Lyon strains of hypertensive rats and the hypertensive New Zealand Black mouse) have identifiable abnormalities in immune function that are associated with their hypertensive disease. Other models (such as partial renal infarct hypertension, post-mineralocorticoid-salt hypertension, and hypertension induced by repeated injections of angiotensin II) also may have primary or secondary immunologic factors contributing to their etiology. Although there is a strong association between alterations in immune function and hypertension, the specific immunologic mechanisms that contribute to the pathogenesis of hypertension are not known. Therefore, further investigation will be necessary to elucidate these mechanisms.
Authors:
D J Dzielak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hypertension     Volume:  19     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-20     Completed Date:  1992-02-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I36-44     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Mississippi Medical Center, Jackson 39216.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Hypertension / immunology*
Immune System / physiology*
Immunity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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