Document Detail


The immune response to severe bacterial infections: consequences for therapy.
MedLine Citation:
PMID:  22397569     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The immune response to a bacterial stimulus starts when pathogen-associated molecular patterns of the bacterial pathogens activate pattern recognition receptors of the innate immune system. This leads to production of proinflammatory and anti-inflammatory mediators aiming to contain infection and drive the clinical signs of sepsis. When sepsis and signs of failing organs are apparent, proinflammatory phenomena have ceased; a hypoinflammatory phase predominates, characterized by anergy of monocytes and apoptosis of T lymphocytes. The above sequence of events seems to differ from one patient to the next. The majority of therapies targeting the immune responses have failed to provide clinical benefit. Immunostimulation with IFN-γ and leukocyte growth factors, hemoperfusion with polymyxin B-embedded fiber column, and macrolides remain the most promising immunomodulators in clinical practice.
Authors:
Evangelos J Giamarellos-Bourboulis; Maria Raftogiannis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  10     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-80     Citation Subset:  IM    
Affiliation:
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
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